The festive fixture list is nearing its end and January is almost upon us, which means a fresh headache for a number of Premier League managers.
The Africa Cup of Nations AND the Asia Cup are both set to start in the new year, which of course means just about every club in the division will be without some key players for an extended period of time. With AFCON, as many as 46 players from the Premier League could be picked and out of action for their clubs.
It is a different story for the Asia Cup, with significantly less Premier League players leaving for the tournament. That's not to say there won't be some notable absences, with the likes of Arsenal, Tottenham and Liverpool all seeing key players jet off.
The AFCON final is not scheduled until February 11, meaning players that reach the final would be sidelined for as many as five weeks. The Asia Cup final kicks off on January 12 and will end a day before the AFCON final on February 10.
With all that being said, Mirror Football has analysed a number of players that are jetting off to Africa and Asia respectively.
Premier League odds and betting tipsAfrica Cup of Nations
* indicates likely to be selected, but potential injury issues.
Arsenal - Mohamed Elneny, injury doubt (Egypt),* Thomas Partey, injury doubt (Ghana)*.
Aston Villa - Bertrand Traore (Burkina Faso).
Bournemouth - Dango Ouattara (Burkina Faso), Antoine Semenyo (Ghana), Hamad Traore (Ivory Coast).
Brentford - Yoane Wissa (DR Congo), Frank Onyeka (Nigeria).
Brighton - Simon Adingra (Ivory Coast), Carlos Baleba, (Cameroon)*, Tariq Lamptey, injury doubt (Ghana)*.
Burnley - Anass Zaroury, selection doubt (Morocco).
Chelsea - Nicolas Jackson (Senegal).
Crystal Palace - Jordan Ayew (Ghana). Cheikhou Kouyate (Senegal).
Everton - Idrissa Gueye (Senegal).
World Cup hero wants Man Utd move as doubts over Harry Maguire's future growFulham - Calvin Bassey (Nigeria), Alex Iwobi (Nigeria). Fode Ballo-Toure, injury doubt (Senegal)*.
Liverpool - Mohamed Salah (Egypt).
Luton - Issa Kabore (Burkina Faso). Pelly Ruddock Mpanzu, injury doubt (DR Congo).*
Manchester City - None.
Manchester United - Andre Onana (Cameroon), Sofyan Amrabat (Morocco). Amad, injury doubt (Ivory Coast)*.
Newcastle United - None.
Nottingham Forest - Willy Boly (Ivory Coast), Ibrahim Sangare (Ivory Coast), Ola Aina (Nigeria), Moussa Niakhate (Senegal), Cheikhou Kouyate (Senegal). Serge Aurier, injury doubt (Ivory Coast)*.
Sheffield United - Yasser Larouci (Algeria), Anis Ben Slimane (Tunisia). Benie Traore, uncapped (Ivory Coast), Ismaila Coulibaly, selection doubt (Mali)*.
Tottenham Hotspur - Yves Bissouma (Mali).
West Ham United - Said Benrahma (Algeria), Mohammed Kudus (Ghana), Nayef Aguerd (Morocco). Maxwell Cornet, selection doubt (Ivory Coast)*.
Wolves - Boubacar Traore (Mali), Rayan Ait-Nouri (Algeria).
Asia Cup
Arsenal - Takehiro Tomiyasu (Japan)
Sheffield United - Saman Ghoddos (Iran)
Brighton - Kaoru Mitoma (Japan)
Liverpool - Wataru Endo (Japan)
Tottenham - Son Heung-Min (South Korea)
Wolves - Hwang Hee-Chan (South Korea)