A NEW mRNA cancer vaccine can reprogram the immune system to attack tumours within 48 hours, a study shows.
The first-ever human clinical trial of four adult patients showed the jab helps fight against the type of aggressive and deadly brain tumour that killed Tom Parker.
It uses similar tech to some Covid vaccines to train the immune system and is also personalised to patients using their own DNA.
Dr Elias Sayour, of the University of Florida, said: “I am hopeful that this could be a new paradigm for how we treat patients, a new platform technology for how we can modulate the immune system.
“I am hopeful for how this could now synergize with other immunotherapies and perhaps unlock those immunotherapies.
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“We showed that you actually can have synergy with other types of immunotherapies, so maybe now we can have a combination approach of immunotherapy.”
mRNA vaccines — like Pfizer and Moderna’s Covid jabs — became widespread during the pandemic and researchers are now redeploying the tech to work on other diseases.
They work by providing a genetic code for the body’s immune system to read and ramp up production of attack cells.
Previous research in mice has shown the jabs are effective in tackling cervical cancer caused by the HPV virus.
The latest study, published in Cell, looked at how mRNA vaccines work against glioblastomas in a human clinical trial.
Glioblastomas are very aggressive brain tumours that affect around 3,200 Brits a year.
The main treatments currently available are surgery, radiotherapy and chemotherapy.
The Wanted’s Tom Parker died from one in March 2022, as did Baroness Margaret McDonagh, a Labour peer, in June 2023.
TV presenter Annabel Giles also lost her life to stage four glioblastoma in November 2023, campaigner Laura Nuttall, who inspired Peter Kay's first gig in four years, died from one in May 2023, and Tessa Jowell, a former Labour cabinet minister, passed away in May 2018.
The study showed results from seven years of research on mRNA brain cancer jabs, including preclinical mouse models.
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It also included a clinical trial of 10 pet dogs that had spontaneously developed terminal brain cancer and had no other treatment options.
RAPID RESPONSE
Results from both showed the jab had promise in treating the disease, prompting further research in humans.
While too early in the trial to assess the clinical effects of the vaccine, the patients either lived disease-free longer than expected or survived longer than expected.
Dr Sayour said: “In less than 48 hours, we could see these tumours shifting from what we refer to as ‘cold’ — immune cold, very few immune cells, very silenced immune response — to ‘hot,’ very active immune response.
“That was very surprising given how quick this happened, and what that told us is we were able to activate the early part of the immune system very rapidly against these cancers, and that’s critical to unlock the later effects of the immune response.”
Researchers will now test the vaccine in a Phase 1 paediatric clinical trial for brain cancer.
