DREAM TEAM brings you all the latest injury, suspension and availability news ahead of Gameweek 5 in one easily digestible dose.
Trent Alexander-Arnold (£5.3m), Dream Team's fifth-most popular defender, will not feature for Liverpool at Molineux in the Saturday lunchtime kick-off.
The creative right-back is also likely to miss the Reds' first Europa League game for the season on Thursday.
Antony (£3.5m) and Jadon Sancho (£2.6m) have been added to Manchester United's list of absentees for widely-reported off-field issues while Raphael Varane (£3.5m) and Mason Mount (£3.3m) are not ready to return to the matchday squad.
Additionally, Sofyan Amrabat's (£3.5m) condition remains something of a mystery and it's unclear at this stage whether the Morocco international will be involved against Brighton on Saturday.
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The social media rumours about Bukayo Saka's (£6.3m) uncertain availability were mostly quashed by Mikel Arteta in the Spaniard's Friday press conference.
Arsenal's gaffer confirmed the England winger has trained normally and told reporters: "There’s nothing to report. Every player has pain or issues, but nothing to worry about."
However, Thomas Partey (£2.7m) will be sidelined for a few more weeks.
Roberto De Zerbi will make a late decision on Evan Ferguson (£3m) following the teenage striker's return to training on Thursday.
The Republic of Ireland starlet, who is among the most-recruited players in the last fortnight, scored a hat-trick in Gameweek 4 but didn't feature for his country during the international break.
Ansu Fati (£3.5m) is expected to make his debut for the Seagulls in some capacity while Pervis Estupinan (£3.8m) may have his minutes managed after a long journey back from Ecuador duty.
Enzo Fernandez (£3.2m) trained today for the first time this week but Mauricio Pochettino said the Argentine midfielder would be "ready" to face Bournemouth this weekend.
Chelsea are also hopeful Reece James (£4.5m) will return before the October international break, a timescale that suggests Malo Gusto (£2.4m) will continue at right-back for the next two or three Gameweeks at least.
Manchester City will be without Kevin De Bruyne (£6.7m), Mateo Kovacic (£3m), Jack Grealish (£4.4m) and John Stones (£5m) for their trip to West Ham on Saturday.
As for the hosts, Edson Alvarez (£2.3m) didn't arrive back into country until 3am due to a delayed flight but David Moyes believes he will be able to call upon the combative midfielder.
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Marc Guehi (£2.7m) is unlikely to play for Crystal Palace having picked up a niggle on England duty in midweek.
Will Osula (£1m), George Baldock (£2m) and John Egan (£2m) all picked up injuries during the international break and are doubtful as Sheffield United prepare to host Tottenham.
As for Ange Postecoglou's side, there are no new updates to report - Son Heung-min (£4.5m) is fine after copping a couple of stiff challenges while representing South Korea.
Sandro Tonali (£2.6m) is a doubt for Newcastle having incurred a thigh injury, though it's not thought to be a long-term concern.
In more positive news for the Magpies, Sven Botman (£3.8m) is in contention to feature against Brentford at St James' Park this weekend having returned to training.
ARSENAL
Injuries: Mohamed Elneny, Jurrien Timber, Thomas Partey
Suspensions: None
ASTON VILLA
Injuries: Tyrone Mings, Emi Buendia, Alex Moreno (doubt), Jacob Ramsey, Tim Iroegbunam, Diego Carlos
Suspensions: None
BOURNEMOUTH
Injuries: Alex Scott, Ryan Fredericks, Emiliano Marcondes, Tyler Adams
Suspensions: None
BRENTFORD
Injuries: Josh Dasilva, Shandon Baptiste, Mikkel Damsgaard (doubt)
Suspensions: Ivan Toney
BRIGHTON
Injuries: Julio Enciso, Evan Ferguson (doubt)
Suspensions: None
BURNLEY
Injuries: Michael Obafemi, Hjalmar Ekdal, Darko Churlinov
Suspensions: None
CHELSEA
Injuries: Reece James, Trevoh Chalobah, Armando Broja, Christopher Nkunku, Beniot Badiashile, Wesley Fofana, Marcus Bettinelli, Carney Chukwuemeka, Romeo Lavia
Suspensions: None
CRYSTAL PALACE
Injuries: Michael Olise, Matheus Franca, Malcolm Ebiowei, Marc Guehi (doubt)
Suspensions: None
EVERTON
Injuries: Seamus Coleman, Dele Alli, Jack Harrison, Youssef Chermiti (doubt)
Suspensions: None
FULHAM
Injuries: Tom Cairney (doubt), Sasa Lukic, Tosin Adarabioyo
Suspensions: None
LIVERPOOL
Injuries: Ibrahima Konate, Thiago Alcantara, Trent Alexander-Arnold
Suspensions: Virgil van Dijk
LUTON
Injuries: Dan Potts, Jordan Clark, Gabriel Osho, Amari’i Bell (doubt), Pelly Ruddock-Mpanzu (doubt)
Suspensions: None
MANCHESTER CITY
Injuries: Kevin De Bruyne, John Stones, Jack Grealish, Mateo Kovacic
Suspensions: None
MANCHESTER UNITED
Injuries: Raphael Varane, Luke Shaw, Mason Mount, Tom Heaton, Amad Diallo, Kobbie Mainoo, Tyrell Malacia, Sofyan Amrabat (doubt)
Suspensions: None
NEWCASTLE
Injuries: Javier Manquillo (doubt), Joe Willock, Emil Krath, Sven Botman (doubt), Sandro Tonali (doubt), Elliot Anderson (doubt)
Suspensions: None
NOTTINGHAM FOREST
Injuries: Serge Aurier (doubt), Danilo, Anthony Elanga (doubt)
Suspensions: None
SHEFFIELD UNITED
Injuries: Rhys Norrington-Davies, Daniel Jebbison, Rhian Brewster, John Fleck, Max Lowe, Ben Osborn, Tom Davies, Will Osula (doubt), George Baldock (doubt), John Egan (doubt)
TOTTENHAM
Injuries: Rodrigo Bentacur, Ryan Sessegnon, Bryan Gil, Giovani Lo Celso (doubt), Alfie Whiteman
Suspensions: None
WEST HAM
Injuries: None
Suspensions: None
WOLVES
Injuries: Joe Hodge, Tommy Doyle (doubt)
Suspensions: None
